人成纤维样滑膜细胞 408-05a Human Fibroblast-Like Synoviocytes
更新日期：2014年03月21日
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Human Fibroblast-Like Synoviocytes (HFLS) provide an excellent cellular model for studying the normal and pathological physiology of synoviocytes and development of joint diseases.
Normal HFLS from Cell Applications, Inc. have been used to examine:
- TNFα – mediated changes in gene expression
- TNF-like weak inducer of apoptosis (TWEAK) contribution to joint inflammation by inducing chemokines and matrix metalloprotease-9, suggesting TWEAK as a new therapeutic target
- The role of miR-124a in arthritis pathogenesis
- C/EBPβ regulation of metalloproteinases and ADAMTS family members in synoviocytes stimulated with IL-1β
- HMW-HA suppression of ADAMTS4 mRNA and protein expression via CD44, p38 MAPK and JNK pathways
- Anti-inflammatory and antirheumatic activity of various compounds, such as NF-κB inhibitors, AGIX-4207, HA–methotrexate conjugates and bucillamine
- Reactive arthritis triggered by chlamydial infection
- Mechanisms of arthritis-like syndrome in patients infected with chikungunya (CHIK) virus
